Understanding Radiation Damage to Cells Using Microbeams
نویسندگان
چکیده
منابع مشابه
Understanding Radiation Damage to Cells Using Microbeams
Cellular micro-irradiation using ion beams is now recognised as a highly versatile technique for understanding how ionising radiation interacts with living cells and tissues. The strength of the micro-irradiation technique lies in its ability to deliver precise doses of radiation to selected individual cells (or sub-cellular targets) in vitro. The application of this technique in the field of r...
متن کاملThe use of microbeams to investigate radiation damage in living cells.
The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no...
متن کاملDNA damage and repair kinetics after microbeam radiation therapy emulation in living cells using monoenergetic synchrotron X-ray microbeams
A novel synchrotron-based approach, known as microbeam radiation therapy (MRT), currently shows considerable promise in increased tumour control and reduced normal tissue damage compared with conventional radiotherapy. Different microbeam widths and separations were investigated using a controlled cell culture system and monoenergetic (5.35 keV) synchrotron X-rays in order to gain further insig...
متن کاملThe use of radiation microbeams to investigate the bystander effect in cells and tissues
Microbeams are ideally suited to the study of so-called ‘non-targeted’ phenomena that are now known to occur when living cells and tissues are irradiated. Non-targeted effects are those where cells are seen to respond to ionising radiation through pathways other than direct damage to the DNA. One such phenomenon is the ‘bystander effect’; the observation that unirradiated cells can be damaged t...
متن کاملReconstruction of human exposure to heavy metals using synchrotron radiation microbeams in prehistoric and modern humans.
OBJECTIVE Teeth can serve as records of environmental exposure to heavy metals during their formation. We applied a new technology - synchrotron radiation microbeams (SRXRF) - for analysis of heavy metals in human permanent teeth in modern and historical samples. METHODS Each tooth was cut in half. A longitudinal section 200 mum in thickness was subjected to the determination of the heavy met...
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ژورنال
عنوان ژورنال: Acta Physica Polonica A
سال: 2006
ISSN: 0587-4246,1898-794X
DOI: 10.12693/aphyspola.109.257